CAS number . . . . . . . . . . . 104-94-9
NIOSH REL. . . . . . . . . . . . 0.5 mg/m3 TWA [skin]
Current OSHA PEL . . . . . . . . 0.5 mg/m3 TWA [skin]
1989 OSHA PEL. . . . . . . . . . Same as current PEL
1993-1994 ACGIH TLV. . . . . . . 0.1 ppm (0.5 mg/m3) TWA [skin]
Description of substance . . . . Yellow to brown, crystalline solid with an
                                 amine-like odor.
LEL. . . . . . . . . . . . . . . Unknown
Original (SCP) IDLH. . . . . . . 50 mg/m3
Basis for original (SCP) IDLH. . Because no data on acute inhalation toxicity
                                 are available for anisidine (o-, p-isomers),
                                 the chosen IDLH is based on chronic data.
                                 ACGIH [1971] reported that mice survived
                                 exposures to 10 to 30 mg/m3 for 2 hours/day,
                                 6 days/week for 1 month; a decrease in the
                                 excitability of nerves was noted [Zaeva and
                                 Fedorova 1962].  Because mice survived 30
                                 mg/m3, 2 hours/day, 6 days/week for 1 month,
                                 a worker should be able to escape from 50
                                 mg/m3 without injury or irreversible health
                                 effects.
Short-term exposure guidelines . None developed

ACUTE TOXICITY DATA

Lethal dose data:

                                                                              
                                     LD50    LDLo                    Derived
Species     Reference         Route (Mg/kg) (mg/kg)   Adjusted LD     Value
______________________________________________________________________________
Rabbit   IARC 1982            oral  2,900    -----   20,300 mg/m3  2,030 mg/m3
Mouse    IARC 1982            oral  1,300    -----    9,100 mg/m3    910 mg/m3
Mouse    Nippon 1956          oral  -----    1,000    7,000 mg/m3    700 mg/m3
Rat      Sziza and Podragyai  oral  1,400    -----    9,800 mg/m3    980 mg/m3
         1957

Other animal data. . . . . . . . Mice have survived exposures to
                                 concentrations of 10 to 30 mg/m3 for 2
                                 hours/day, 6 days/week for 1 month with
                                 a only decrease in the excitability of nerves
                                 noted [Zaeva and Fedorova 1962].
Human data . . . . . . . . . . . None relevant for use in determining the
                                 revised IDLH.

Revised IDLH: 50 mg/m3 [Unchanged]
Basis for revised IDLH: Based on subchronic inhalation toxicity data in animals [Zaeva and Fedorova 1962], the original IDLH for p-anisidine of 50 mg/m3 is not being revised at this time.

REFERENCES:

1. ACGIH [1971]. Anisidine (o-, p-isomers). In: Documentation of the threshold limit values for substances in workroom air. 3rd ed. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, p. 14.
2. IARC [1982]. IARC monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 27. Lyon, France: World Health Organization, International Agency for Research on Cancer, p. 63.
3. Nippon Yakurigaku Zasshi (Japanese Journal of Pharmacology) [1956]; 52:215-221 (in Japanese).
4. Sziza M, Podragyai L [1957]. Toxikologische untersuchung einiger in der ungarischen industrie zur anwendung gelangenden aromatischen amidoverbindungen. Arch Gewerbepath Gewerbehyg 15:447-456 (in German).
5. Zaeva GN, Fedorova VI [1962]. Toxsikol Nov Prom Khim Vesh 4:91 (in Russian).