International Chemical Safety Cards p-ANISIDINE ICSC: 0971 1-Amino-4-methoxybenzene 4-Methoxyaniline C7H9NO / H2NC6H4OCH3 Molecular mass: 123.2 ICSC #    0971 CAS #     104-94-9 RTECS # BZ5450000 UN #        2431 EC #         612-112-00-2 March 25, 1999 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. Gives off irritating or toxic fumes (or gases) in a fire. NO open flames. Powder, water spray, foam, carbon dioxide. EXPLOSION EXPOSURE PREVENT DISPERSION OF DUST! STRICT HYGIENE! IN ALL CASES CONSULT A DOCTOR!  •INHALATION Blue lips or finger nails. Blue skin. Confusion. Convulsions. Dizziness. Headache. Nausea. Unconsciousness. Ventilation, local exhaust, or breathing protection. Fresh air, rest. Refer for medical attention.  •SKIN MAY BE ABSORBED! Blue lips or fingernails. Blue skin. Protective gloves. Protective clothing. Remove contaminated clothes. Rinse skin with plenty of water or shower.  •EYES Redness. Face shield. or eye protection in combination with breathing protection if powder. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Blue lips or fingernails. Blue skin. (See Inhalation). Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give plenty of water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Sweep spilled substance into containers; if appropriate, moisten first to prevent dusting then remove to safe place. Do NOT let this chemical enter the environment. (Extra personal protection: chemical protection suit including self-contained breathing apparatus). Separated from strong oxidants, acids, acid anhydrides, acid chlorides, chloroformates and food and feedstuffs. Do not transport with food and feedstuffs. T+ symbol N symbol R: 26/27/28-33-50 S: 1/2-28-36/37-45-61 UN Hazard Class: 6.1 UN Packing Group: III SEE IMPORTANT INFORMATION ON BACK ICSC: 0971 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards p-ANISIDINE ICSC: 0971 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: CRYSTALS , WITH CHARACTERISTIC ODOUR. PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing toxic fumes of nitrogen oxides. The solution in water is a weak base. Reacts with acids, acid anhydrides, acid chlorides, chloroformates and strong oxidants. OCCUPATIONAL EXPOSURE LIMITS: TLV: 0.1 ppm (as TWA) (A4) (skin) (ACGIH 1998). OSHA PEL: TWA 0.5 mg/m3 skin NIOSH REL: TWA 0.5 mg/m3 skin NIOSH IDLH: 50 mg/m3 ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. INHALATION RISK: A harmful contamination of the air will be reached rather slowly on evaporation of this substance at 20°C; on spraying or dispersing, however, much faster. EFFECTS OF SHORT-TERM EXPOSURE: The aerosol irritates the eyes. The substance may cause effects on the kidneys and blood , resulting in kidney impairment and formation of methaemoglobin. The effects may be delayed. Medical observation is indicated. See Notes. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 243°C Melting point: 57°C Relative density (water = 1): 1.1 Solubility in water: moderate Vapour pressure, Pa at 25°C: 0.8 Relative vapour density (air = 1): 4.3 Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0 Flash point: 122°C Auto-ignition temperature: 515°C Octanol/water partition coefficient as log Pow: 0.95 ENVIRONMENTAL DATA The substance is toxic to aquatic organisms. N O T E S Depending on the degree of exposure, periodic medical examination is indicated. Specific treatment is necessary in case of poisoning with this substance; the appropriate means with instructions must be available. Also consult ICSC #0970 o-Anisidine. ADDITIONAL INFORMATION ICSC: 0971 p-ANISIDINE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.