International Chemical Safety Cards TRIBUTYLTIN OXIDE ICSC: 1282 Hexabutyldistannoxane Tri-n-butyltin oxide TBTO C24H54OSn2 Molecular mass: 596.07 ICSC #    1282 CAS #     56-35-9 RTECS # JN8750000 UN #        3020 EC #         050-008-00-3 March 26, 1998 Peer reviewed TYPES OF HAZARD/ EXPOSURE ACUTE HAZARDS/ SYMPTOMS PREVENTION FIRST AID/ FIRE FIGHTING FIRE Combustible. NO open flames. In case of fire in the surroundings: use appropriate extinguishing media. EXPLOSION EXPOSURE PREVENT GENERATION OF MISTS! STRICT HYGIENE!  •INHALATION Abdominal cramps. Cough. Diarrhoea. Laboured breathing. Nausea. Sore throat. Vomiting. Symptoms may be delayed (see Notes). Ventilation, local exhaust, or breathing protection. Fresh air, rest. Half-upright position. Refer for medical attention.  •SKIN MAY BE ABSORBED! Redness. After delay skin burns. Protective gloves. Protective clothing. Rinse and then wash skin with water and soap. Refer for medical attention.  •EYES Redness. Pain. Safety spectacles face shield or eye protection in combination with breathing protection. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.  •INGESTION Abdominal cramps. Diarrhoea. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Give plenty of water to drink. Refer for medical attention. SPILLAGE DISPOSAL STORAGE PACKAGING & LABELLING Do NOT wash away into sewer. Carefully collect remainder, then remove to safe place. Do NOT let this chemical enter the environment. Chemical protection suit including self-contained breathing apparatus. Provision to contain effluent from fire extinguishing. Severe marine pollutant. Note: A T symbol N symbol R: 21-25-36/38-48/23/25-50/53 S: 1/2-35-36/37/39-45-60-61 UN Hazard Class: 6.1 UN Packing Group: II SEE IMPORTANT INFORMATION ON BACK ICSC: 1282 Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 1994. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards TRIBUTYLTIN OXIDE ICSC: 1282 I M P O R T A N T D A T A PHYSICAL STATE; APPEARANCE: LIQUID PHYSICAL DANGERS: CHEMICAL DANGERS: The substance decomposes on burning producing toxic fumes . OCCUPATIONAL EXPOSURE LIMITS: TLV: (as Sn) 0.1 mg/m³ as TWA; 0.2 mg/m³ as STEL; (skin); A4 (not classifiable as a human carcinogen); (ACGIH 2004). MAK: 0.0021 ppm, 0.05 mg/m³; Peak limitation category: I(1); Pregnancy risk group: C; (DFG 2004). ROUTES OF EXPOSURE: The substance can be absorbed into the body by inhalation of its aerosol, through the skin and by ingestion. INHALATION RISK: Evaporation at 20°C is negligible; a harmful concentration of airborne particles can, however, be reached quickly. EFFECTS OF SHORT-TERM EXPOSURE: The substance is severely irritating to the eyes , the skin . Inhalation of the aerosol may cause lung oedema (see Notes). The substance may cause effects on the thymus , resulting in depression of the immune function. EFFECTS OF LONG-TERM OR REPEATED EXPOSURE: PHYSICAL PROPERTIES Boiling point: 173°C Melting point: <-45°C Relative density (water = 1): 1.17 at 20°C Solubility in water: poor Vapour pressure, Pa at 20°C: 0.001 Flash point: 190°C c.c. Octanol/water partition coefficient as log Pow: 3.19 ENVIRONMENTAL DATA The substance is very toxic to aquatic organisms. Bioaccumulation of this chemical may occur along the food chain, for example in fish and in molluscs. This substance does enter the environment under normal use. Great care, however, should be given to avoid any additional release, e.g. through inappropriate disposal. N O T E S The symptoms of lung oedema often do not become manifest until a few hours have passed and they are aggravated by physical effort. Rest and medical observation is therefore essential. Immediate administration of an appropriate inhalation therapy by a doctor or a person authorized by him/her, should be considered. Card has been partly updated in October 2004 and April 2005. See sections Occupational Exposure Limits, EU classification, Emergency Response. Transport Emergency Card: TEC (R)-61GT6-II ADDITIONAL INFORMATION ICSC: 1282 TRIBUTYLTIN OXIDE (C) IPCS, CEC, 1994

IMPORTANT LEGAL NOTICE: Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.